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ea0004dp11 | Diabetes, metabolism and cardiovascular | SFE2002

PPARalpha activation during late pregnancy improves insulin action and attenuates glucose-stimulated insulin hypersecretion

Smith N , Greenwood G , Sugden M , Holness M

Lipid sensing by pancreatic beta cells is co-ordinated through the expression and activity of peroxisome proliferator-activated receptors (PPARs). Through their action to lower triacylglycerol delivery to peripheral tissues, PPARalpha activators also oppose insulin resistance by relieving inhibition of insulin-stimulated glucose disposal. Mid to late pregnancy is an insulin-resistant state associated with hypertriglyceridaemia. We investigated regulatory interactions between P...

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ea0004dp12 | Diabetes, metabolism and cardiovascular | SFE2002

Activation of peroxisome-proliferator-activated receptor (PPAR) alpha reverses high-fat induced insulin hypersecretion in perifused pancreatic islets

Greenwood G , Smith N , Holness M , Sugden M

Activation of PPARalpha pharmacologically by WY14,643 enhances insulin sensitivity in insulin-resistant high-fat-fed rats. PPARalpha is expressed in pancreatic islets, where it affects genes involved in lipid metabolism. We investigated effects of PPARalpha activation by WY14,643 on glucose-stimulated insulin secretion (GSIS) in a rat model of high-fat feeding in which insulin resistance is observed in conjunction with compensatory insulin hypersecretion. To identify persisten...

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Endocrine Abstracts

PPARalpha activation during late pregnancy improves insulin action and attenuates glucose-stimulated insulin hypersecretion

Activation of peroxisome-proliferator-activated receptor (PPAR) alpha reverses high-fat induced insulin hypersecretion in perifused pancreatic islets

BiosciAbstracts